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Gallstones are hard pieces of stone-like material that can form if your bile (digestive juices) has too much cholesterol in it. The gallbladder has one purpose only: to store bile, which helps digest fats in the small intestine. But bile can become concentrated and thicken. Eventually, bile salts can combine with cholesterol to form stones. These stones can block the flow of bile from the gallbladder; gallstones are composed of a combination of crystallized cholesterol deposits or calcium crystals ionized with bilirubin. This is typically manifested as pain in the upper right quadrant of the abdomen. Sometimes a gallstone can move out of the gallbladder and block the openings (ducts) to the pancreas (ampulla of Vata.) It is thought that the blockage causes a disruption in the chemical reactions that occur within the pancreas. This could lead to the activation of trypsin inside the pancreas and trigger the process of inflammation

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