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Genes aren't typically considered "healthy" or "unhealthy", but I suppose a healthy gene might be equated with a gene with normal function. Mutations in genes can lead to defective genes, the sort of genes you might call "unhealthy". Normally, genes encode proteins that carry out important structural and functional processes within and between cells of the body. Defective genes might encode a faulty protein that can no longer carry out its normal task.

Whether the genetic mutation results in such a faulty protein depends on a number of things, such as the function of the normal protein, the type of genetic mutation, the activity of the faulty protein, etc. This might sound complex: it is. Understanding the difference between healthy and unhealthy genes requires quite a bit of knowledge about genetics, the relationship between genes and environment, how cells operate and communicate, etc. It's no easy task.

In your question you ask specifically about genes on chromosome 21. The discussion of genetic mutation doesn't need to be specifically targeted to genes on chromosome 21 unless you have a specific gene, mutation, or disease in mind. Since this is categorized under Down syndrome, I suppose you might be thinking of a single gene defect that could cause Down syndrome. I'm not aware of one, but this is no my area of expertise. Down syndrome is usually caused by trisomy 21 or a translocation involving chromosome 21. These two processes don't involve single gene defects, but rather duplication of a large number of genes within a single cell, which causes Down syndrome.

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16y ago

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