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Everyone is aware that caffeine is useful for overcoming tiredness, but not many people understand how. Caffeine actually affects different tissues in different ways; the most stimulating effect actually occurs in the brain. Normally when you start to get sleepy, adenosine molecules bind to receptor proteins stimulating drowsiness. Because caffeine is similar in structure to the adenosine molecules, it binds to the receptors instead, blocking the site from the adenosine. Caffeine also stimulates epinephrine in the heart and liver cells, increasing heart rate and stimulating glycogen conversion to glucose.

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