How does cancer cause cachexia?

Answer 1

Cancer causes cachexia through a complex interplay of factors, including the release of pro-inflammatory cytokines, metabolic changes, and tumor metabolism that alters nutrient utilization. These factors lead to increased energy expenditure and muscle wasting, as the body breaks down its own tissues for energy. Additionally, cancer can disrupt normal appetite regulation, contributing to weight loss and systemic weakness. Together, these mechanisms result in the characteristic muscle and fat loss seen in cachexia.