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In a regular nerve synapse, not exposed to any antigens and in a healthy body, inhibitory, or preventative, neurotransmitters are released constantly to prevent the release of dopamine (<----neurotransmitters), a natural painkiller(or mood-lifter). When the body is severely damaged or injured, natural opiates are released and travel to the inhibitory neurotransmitters. When the opiates arrive at the inhibitory neurotransmitters, they enter the opiate receptors. Once this occurs, the dopamine neurotransmitters can be released and travel to dopamine receptors, to travel through neurons to the rest of the body.

Once heroin is brought into the body, people feel a short, but immediate, high. The heroin simulates natural opiates. The heroin travels through the body to the inhibitory neurotransmitters and to the opiate receptors. Once the body has received the heroin, the inhibitory neurotransmitters are no longer released, at least until the heroin wears off. The dopamine is now released and the drug user feels a high from the effects of the dopamine.

There is a great source that explains not only the effects of heroin on the synapse, but several other drugs too.

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13y ago

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