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Encephalitis lethargica or von Economo disease is an atypical form of encephalitis. Also known as "sleepysickness" (distinct from tsetse fly-transmitted sleeping sickness), therapies, and treatments to help symptoms were often steroids.
Treatment is then based on the systems. Levodopa (L-DOPA) and other anti-Parkinson drugs often produce dramatic responses; however, most patients given L-DOPA experience help that is short lived.
L-DOPA crosses the protective blood–brain barrier, whereas dopamine itself cannot. Therefore, L-DOPA is used to increase dopamine concentrations in the treatment of Parkinson's disease and EL.
The epidemic of encephalitis lethargica (EL) was widespread throughout the world during 1917–1926, affecting half a million persons. The acute phase was lethal for many. The cause was unknown and many thought that the influenza virus was to blame There was a very lethal 'flu outbreak at this time (Of course, there were zombie theories also).
The data now supports the hypothesis that the VLP observed in EL tissue is an Enterovirus.

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