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malaria can be lethal, for example, malaria caused by the African strain Plasmodium falciparum can cause cerebral malaria which leads coma and often death. Although well over 1 million people are killed each year by the parasite, most cases of malaria are not fatal and often very treatable.

The lethality often depends upon the exact strain which one has been infected with and the chance effects of the strain, for example, where it sequesters (gathers). Sequestration in the brain can often be fatal and sequestration in the placenta can lead to the death of unborn babies. Blood clots can form when the parasite sequesters in the blood vessels and the fever itself can prove detrimental.

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