The Clarke system utilizes the layers of the dermis and the skin appendages present at that layer to identify the depth of penetration.
The Breslow system uses the absolute measurement of depth.
Though useful conceptually, the Clarke system is used less frequently because of the fact that skin is of different thickness in different regions of the body.
Factors that create a predisposition to malignant melanoma include a family history of the disease, having fair skin that burns easily, a history of excessive sun exposure or sunburns, having numerous moles or atypical moles, and a weakened immune system. Additionally, individuals with a personal history of melanoma or other types of skin cancer are also at an increased risk.
Melanoma is a cancer of the skin. And the skin is technically a part of the integumentary system.
For those with familial tendencies for malignant melanoma, genetic counseling may be appropriate. Psychological counseling may be appropriate for anyone having trouble coping with a potentially fatal disease.
It turns out that the Breslow measurement is more reproducible and thus more useful; therefore, for purposes here, depth of penetration by absolute measurement (Breslow) is used in local staging.
neuroblastoma
It is highly unusual for malignant brain tumors to spread beyond the central nervous system
lymphoma
If the melanoma is spreading through the lymph system, some of the tumor may grow there, resulting in a nodule part way between the primary site and the original lymph node.
The TNM classification system is designed to classify malignant tumors
There is no any specific demarcation to say whether it is benign or malignant. We have WHO grading system which tells us that only cellular features of malignancy are present. But there is no metastasis so i would say that it is benign with malignant potential.