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The autonomic nervous system regulates the cardiovascular system. The parasympathetic division innervates the heart via the vagus nerve. The sympathetic division also innervates the heart, but additionally, it supplies innervation to the smooth muscle lining blood vessels. The sympathetic division has a substantial effect on blood pressure, and on local blood flow, via constriction of arterioles.

The cardiovascular system is important to maintain supply of oxygen and nutrients, and removal of wastes, from the nervous system.

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