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For many years, the hypothalamus was thought to be the key to control of food intake. This view derived from classic experiments in which food intake was studied in rats with lesions in various areas of the brain. Such studies clearly identified two regions in the hypothalamus that dramatically influence feeding behavior: * Lateral hypothalamus (hunger center): animals with lesions in this area become anorectic and lose weight. * Ventromedial hypothalamus (satiety center): animals with lesions in this area overeat and become obese. Subsequent studies showed that, although these hypothalamic centers are clearly very important in controlling hunger and satiety, they don't explain the whole story.

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