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First intention healing, also known as primary intention, occurs when a wound's edges are brought together, typically through sutures or staples, leading to minimal scarring and a quicker recovery. In contrast, second intention healing involves the wound healing from the bottom up, allowing granulation tissue to form, which can result in a larger scar and a longer healing time. This process is often seen in larger, open wounds where closure isn't feasible. Overall, the key difference lies in the method of closure and the healing time involved.

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