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Normal brain functioning depends on several aspects of normal liver functioning. For example, the liver supplies certain nutrients to the brain that the brain itself cannot produce. The liver also cleanses the blood of substances that could damage brain cells (neurotoxins). Although the brain is protected from many neurotoxic substances by the blood-brain barrier - a property of blood vessels in the brain that prevents passage of many compounds from the blood into the brain tissue - certain neurotoxins can penetrate that barrier. These substances - which include ammonia, manganese, and other chemicals - can enter the brain at least to some extent unless they are effectively removed from the blood by the liver.

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