How is the brain affected by tobacco?

Answer 1

nicotine is a chemical that acts on nicotinic acetlycholine receptors, which are neurotransmitters in the brain. nicotine also releases dopamine, a reward system chemical ... it also acts as an MAOI inhibitor, monoamine oxidase breaks down other neurotransmitters such as dopamine, serotonin and norepinephrine. so it acts on alot of chemicals, some directly and some indirectly by inhibiting the breakdown of the neurotransmitters.

Answer 2

Tobacco itself does not appear to put holes in the brain, however, the main component of the drug, THC, may be involved in changing brain chemistry which can result in behavioral effects. These effects are more evident the earlier exposure begins. The toxic effect of cigarettes is generally from additives. It will not, however, put holes in your brain.

Answer 3

Exogenous nicotine from tobacco stimulates nicotinic cholinergic receptors. Cells possessing these receptors may down regulate their receptor concentrations, leading to 'addiction' or craving for nicotine.

Nicotinic receptors are found on the post-synaptic membrane (dendrite surface) of most cells in the human body, including the brain. Effects vary vastly, but generally there is a sympathetic response on much of the body via descending pathways originating in the limbic system, medulla, and motor cortex et al. This is the cause of the short-lived 'rush' or 'high' from a nicotine dose.