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The easy answer is, it depends. As with any disease, people respond and recover in different ways and in different periods of time. I received the vaccine in June 2006 and had the typical nasty, blistery lesion that grew to about the size of a nickle over a period of about 10 days. It then gradually dried and reduced in size for another 2 weeks before the scab fell off. Total time to heal: ~30 days. It is important to note that the blister and scab material is infectious and we were advised to treat it as biologically hazardous waste. All bandages used to cover the vaccine site and the final scab had to be put in ziploc bags and brought in to the medical clinic for proper disposal.

Some people have existing immunity, either from previous vaccination or exposure to the virus, and they will have little, if any, reaction to the vaccine. I have seen people get a tiny little blister that heals up and disappears in less than a week and also people who have no reaction to the vaccine at all. Some others have had the scab hang on for more than 6 weeks.

At the other end of the spectrum, a complication of the vaccine can occur (particularly in immune compromised individuals or young children) that results in disseminated vaccinia (the virus used in the vaccine). This causes a rash that spreads from the original vaccine site (can cover the whole body), it can get into the eyes and cause occular damage but the most severe complication is if it enters the brain. It is important to seek medical attention if a rash develops anywhere other than the vaccine site. It can take months to recover from these complications. This is why it is important to keep the vaccine site covered and treat all bandages and the scab as biological waste. There have been cases of people unintentionally infecting their spouses, children and other contacts after receiving the vaccine.

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14y ago

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