Hemophilia is passed down from mother to son. It is extremely
rare for a woman to have hemophilia. It is necessary, though, for
a woman to be a carrier of the disorder for her son to acquire this
disorder. Females have two X chromosomes whereas males only
have one. When a boy is born, he takes one X chromosome from
his mother and one Y chromosome from his father. Therefore, he
can only get hemophilia through his mother.
Example One:
Mother(Carrier)+Father(Non-Affected)=50% chance of their son
acquiring the disorder and 50% chance of their daughter being a
carrier.
Example Two:
Mother(Non-Affected)+Father(Hemophiliac)=All sons will be
non-affected and all daughters will be carriers.
Males.
Male hemophiliacs inherit it from their mother, because hemophilia is only on the X gene and males only have one and it is from their mother.
Hemophilia is sex linked. Males inherit from their mother, daughters are carriers if the defective gene is inherited from one of either parent. A female must inherit two copies of the defective allele to have hemophilia .
Hemophilia occurs in the X chromosome, and males are the genders that have the X chromosome.
Anyone can inherit hemophilia. In most cases, it is a man whose mother is a carrier of the disease. It is extremely rare for a woman to have hemophilia but it is not uncommon for one to be a carrier. It is even possible for someone whose family has no record of hemophilia to get it through gene mutations.
There are no hard answers to this, it depends strictly on luck. The statistics are though not very good for their children. Statisically the couple have a chance of having a normal son, a daughter that is a carrier for hemophilia, a daughter with hemophilia and a son with hemophia.
Recessive?? (i.e., you would need to inherit one from each parent to have hemophilia)
Hemophilia
The gene for hemophilia is found on the 'X' human chromosome. However it is a recessive gene so if a woman (who has two 'XX' chromosomes) has one bad 'X' and one good 'X' she will not have hemophilia but will be a carrier .If she has female children and their father is not a hemophiliac, then half of her daughters may carry the bad 'X' chromosome but non will manifest the disease.However, if her children are male then her sons will have an 'X' chromosome inherited from her and a 'Y' chromosome inherited form the father and there is a 50% chance that the 'X' chromosome inherited will be the bad one. If the son inherits the bad 'X' he will be a hemophiliac and if he lives to father any daughters then all these daughters will be hemophilia carriers (because they must inherit his (bad) 'X' chromosome).It is possible for a woman to manifest hemophilia if the mother is a carrier and the father is a hemophiliac. In this case it is possible for a daughter to inherit the bad 'X' from the father and the mother's bad 'X' giving the daughter two bad 'X' chromosomes.
It is estimated that about 20,000 males in the US are currently living with hemophilia. Hemophilia is a rare genetic blood disorder that primarily affects males. Treatment and management of hemophilia have significantly improved over the years.
To determine how many males have hemophilia from a pedigree, you would need to examine the inheritance pattern shown in the diagram. Hemophilia is an X-linked recessive disorder, so it primarily affects males. Count the males that are shaded or marked in the pedigree to identify those with hemophilia. Without the specific pedigree, I can't give an exact number.
Approximately 1 in 5000 males born have hemophilia. Approximately 1 in 10,000 children have hemophilia.