How many cannabinoid receptors in the human body?

Answer 1

The endocannabinoid system is a ubiquitous lipid signaling system that appeared early in evolution and has important regulatory functions throughout the body in all vertebrates. It consists of a family of G-protein-coupled receptors, the cannabinoid receptors (CB1 found in the brain and many peripheral tissues, and CB2, primarily found in immune cells); endoligands to activate these receptors; and two enzymes, the fatty acid amide hydrolase and the monoacylglycerol lipase, to metabolize the endoligands. The endoligands of the cannabinoid receptor system, small molecules derived from arachidonic acid, are called endocannabinoids.

The main endocannabinoids, anandamide (arachidonoylethanolamide) and 2-arachidonoylglycerol, bind primarily to CB1 and CB2 receptors, but also to the vanilloid receptor producing a wide diversity of effects since they function as agonists, antagonists and partial antagonists. (Cannabinoids function as antagonists to the vanilloid receptor, a.k.a. the capsaicin receptor, since it can be activated by capsaicin and is involved in the transmission and modulation of pain.)

reference: greenbloomdotorg