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Fragile X syndrome is caused by a mutation that prevents the Fragile X mental retardation (Fmr-1) gene from being transcribed. This gene is located on the X chromosome (the sex chromosome). Since males only carry one of these chromosomes, they are twice as likely to be affected by the mutation than females.
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What cause fragile X syndrome?
The fragile X syndrome is a genetic disorder caused by mutation of the FMR1 gene on the X chromosome.
Why are males more likely to have fragile X syndrome?
males have only one copy of the X chromosome. Males who inherit the full mutation are expected to have mental impairment. A female's normal X chromosome may compensate for her chromosome with the fragile X gene mutation
Fragile X syndrome affects only females?
No, Fragile X is on the X chromosome. Females have 2 X chromosomes and Males have an X and a Y Chromosome. Therefore, both males and females can have Fragile X (they can have the full mutation or be carriers). Males are usually more severly affected because they have only one X Chromosome.
What is an example of a genetic disorder that is caused by insertion of extra codons in the X sex chromosome?
Fragile X Syndrome
What is an example of a genetic disorder that is caused by insertion of extra codons in x sex chromosome?
Fragile X Syndrome
What is an examples of a genetic disorder that is cause by insertion of extra codons in the X sex chromosome?
Fragile X Syndrome
What is an example of a genetic disorder that is caused by insertion of extra codons of the X sex chromosome?
Fragile X Syndrome
What is an example of a genetic disorder that is caused by insertion of an extra codons in the X sex chromosome?
Fragile X Syndrome
How did martin bell discover Fragile x syndrome?
Martin Bell discovered Fragile X syndrome in 1969 when he observed a family with multiple members exhibiting intellectual disabilities and behavioral issues. He noted a specific physical characteristic, an abnormality on the X chromosome, which he termed "Fragile X." This discovery laid the groundwork for further research that eventually identified the genetic mutation responsible for the syndrome. Subsequent studies confirmed that Fragile X syndrome is linked to the expansion of a repeat sequence in the FMR1 gene on the X chromosome.
What is the karyotype for fragile X?
The karyotype for fragile X syndrome typically shows a normal chromosomal structure, but it is characterized by a mutation in the FMR1 gene located on the X chromosome. This mutation involves the expansion of CGG repeats, often exceeding 200 repeats, leading to a fragile site on the X chromosome that can appear as a constriction or gap during chromosomal analysis. The presence of this fragile site is associated with the developmental and cognitive features of fragile X syndrome.
Is fragile x syndrome sex linked?
Yes. It is found as a mutation on the X chromosome (a sex chromosome) so it is sex linked. The gene for Fragile X is carried on the X chromosome. Because both males (XY) and females (XX) have at least one X chromosome, both can pass on the mutated gene to their children.
Is fragile X syndrome related to klinefelster?
No, Klinefelter is due to an extra chromosome, Fragile X is due to the FMR1 gene being turned off and producing no FMR1 protein
