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Nicotine can typically be detected in the bloodstream for about 1 to 3 days after the last use, depending on factors like frequency of use and individual metabolism. However, cotinine, a metabolite of nicotine, can remain in the system for up to 1 to 2 weeks. To have a clean blood test for nicotine, it's generally recommended to be nicotine-free for at least 1 to 2 weeks.

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