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Each flu season is unique, but it is estimated that, on average, approximately 5% to 20% of U.S. residents get the flu, and more than 200,000 persons are hospitalized for flu-related complications each year. About 36,000 Americans die on average per year from the complications of flu.

Flu deaths cannot be accurately counted, only estimated. Most people who die from seasonal flu-related complications are not tested for flu, and many seasonal flu-related deaths occur one to two weeks after the initial infection.

Even when people are tested, most flu tests will only detect flu in the first week, and some commonly used tests are less sensitive than that and can provide false negative results even in the first week.

A person with the flu may develop a secondary bacterial co-infection (such as bacterial pneumonia), and influenza can aggravate an existing chronic illness (such as congestive heart failure or chronic obstructive pulmonary disease), leading to the reported cause of death not mentioning flu.

States are not required to report individual seasonal flu cases or deaths of people older than 18 years of age to CDC, and seasonal influenza is infrequently listed on death certificates of people who die from flu-related complications.

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