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In the 1970's, studies indicated that as many as 1 in 500 males could have an extra chromosome that leads to the XXY combinantion that is known as Klienfelter Syndrome. Even though it is one of the most common chromosomal abnormalities, a very small percentage of males ever develop the symptoms. For those who develop the symptoms, one of which is breast development, their risk of getting Breast cancer is almost equal to that of women.

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