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The intestine can be pinched, cut, or burned without generating a pain signal. However, stretching and pressure can cause severe intestinal pain, even from something as relatively harmless as a trapped gas bubble. The brain cannot identify the precise source of intestinal pain, which is difficult to locate and is likely to be felt over a large area.

Intestines bleed at the slightest bump or cut, most ostomy patients can attest to this.

Routine hygene of a stoma (the end of the intestine protruding from the abdomen) such as washing or wiping can cause profuse bleeds but no pain. Block that same intestine off for too long and the pain can be excruciating.

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