When the kidneys fail, they are unable to effectively filter waste products from the blood, including urea. As a result, urea accumulates in the bloodstream, a condition known as uremia. In severe cases, patients may require dialysis to artificially remove urea and other waste products from their blood, or they may need a kidney transplant to restore normal kidney function. Without treatment, high levels of urea can lead to serious health complications.
When it is not properly excreated from body & its accumulation takes place .
Kidney
The kidney gets rid of urea, a waste product generated from the breakdown of proteins in the body. Urea is removed from the blood by the kidneys and excreted in the urine.
Urea is removed in the kidneys and sent to the bladder.
in this the kidney contain less urea
If the kidney stopped functioning, the intracellular concentration of urea would increase due to impaired excretion. In contrast, the extracellular concentration of urea would also increase due to the diminished clearance of urea from the blood.
The presence of urea in the body typically indicates proper kidney function, as urea is a waste product that is excreted by the kidneys. Elevated levels of urea may suggest dehydration, kidney disease, or other health conditions that affect the kidneys.
The clinical significance of Urea is that it helps a doctor tell what is wrong with a patient. In order to do so, because of the nitrogen found within Urea, it can change the color of one's own urination.
Nitrogen waste in form of urea. This combines with water to form urine.
kidney
Urea
Urea is one of the substances in urine, and urine is in your blood stream until the kidney extract the urine from your blood.