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It depends on the type of gangrene. "Dry" gangrene is primarily caused from local loss of blood circulation to the leg without infection. It typically appears as slowly darkening to black dead limb (usually toes or fingers, however). If secondary infection doesn't occur, there is a fair chance the dead part will separate itself ("autoamputate") and the remaining stump heal with time. "Wet" gangrene, on the other hand, is severe infection happening concurrently with impaired blood flow to the limb. The disease process can lead to death in days/weeks, depending on the aggressiveness of the infectious agent, concurrent medical problems, and corollary care given the patient. High fever from septicemia (infection in blood stream) leads to resistant hypotension (low blood pressure) which, in turn, leads to multi-organ failure.

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