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An HBA2 level greater than 3 percent typically indicates the presence of beta-thalassemia, but it does not definitively determine whether the condition is major or minor. In beta-thalassemia minor, the HBA2 level is usually elevated, while in beta-thalassemia major, the level can also be elevated but is accompanied by more severe anemia and additional clinical symptoms. A thorough evaluation, including genetic testing and clinical assessment, is necessary to accurately diagnose the specific type of thalassemia.
What else can I help you with?
When a child has HbA2 of 2.2 and HbF of 98 with no Blood Transfusion and maintains Hb of 8 to 9 which type of thalassaemia it can be called?
Most probably he has beta thalassemia major, or Cooley's anemia What is the age of child ? If it is below 2 years it may be thalassemia major.
Differences between hba1 and hba2 in normal blood?
HbA1 is the predominant form of hemoglobin in adults, comprising about 97-98% of total hemoglobin. HbA2, on the other hand, is a minor component of adult hemoglobin, accounting for 2-3% of total hemoglobin. The main distinction between the two lies in their protein composition, with HbA1 primarily made up of 2 alpha and 2 beta globin chains, while HbA2 consists of 2 alpha and 2 delta globin chains.
How many genes are there for the four polypeptides in haemoglobin?
Human hemoglobin consists of four polypeptide chains: two alpha (α) and two beta (β) chains. The genes responsible for these chains are HBA1 and HBA2 for the alpha chains, and HBB for the beta chains. Therefore, there are three genes associated with the four polypeptides in hemoglobin.
Hemoglobin electrophoresis?
DefinitionHemoglobin electrophoresis is a test that measures the different types of the oxygen-carrying protein (hemoglobin) in the blood.Alternative NamesHb electrophoresis; Hgb electrophoresis; Electrophoresis - hemoglobinHow the test is performedBlood is typically drawn from a vein, usually from the inside of the elbow or the back of the hand. The site is cleaned with germ-killing medicine (antiseptic). The health care provider wraps an elastic band around the upper arm to apply pressure to the area and make the vein swell with blood.Next, the health care provider gently inserts a needle into the vein. The blood collects into an airtight vial or tube attached to the needle. The elastic band is removed from your arm.Once the blood has been collected, the needle is removed, and the puncture site is covered to stop any bleeding.In infants or young children, a sharp tool called a lancet may be used to puncture the skin and make it bleed. The blood collects into a small glass tube called a pipette, or onto a slide or test strip. A bandage may be placed over the area if there is any bleeding.How to prepare for the testNo special preparation is necessary for this test.How the test will feelWhen the needle is inserted to draw blood, some people feel moderate pain, while others feel only a prick or stinging sensation. Afterward, there may be some throbbing.Why the test is performedYou may have this test if your health care provider suspects that you have a disorder caused by abnormal forms of hemoglobin (hemoglobinopathy).Many different types of hemoglobin (Hb) exist. The most common ones are HbA, HbA2, HbF, HbS, HbC, Hb H, and Hb M. Healthy adults only have significant levels of HbA and HbA2.Some people may also have small amounts of HbF (which is the main type of hemoglobin in an unborn baby's body). Certain diseases are associated with high HbF levels (when HbF is more than 2% of the total hemoglobin).HbS is an abnormal form of hemoglobin associated with sickle cell anemia. In people with this condition, the red blood cells sometimes have a crescent or sickle shape. The cells easily break down, or can block small blood vessels.HbC is an abnormal form of hemoglobin associated with hemolytic anemia. The symptoms are much milder than they are in sickle cell anemia.Other, less common, abnormal Hb molecules cause anemias.Normal ValuesIn adults, these hemoglobin molecules make up the following percentages of total hemoglobin:Hb A: 95% to 98%Hb A2: 2% to 3%Hb F: 0.8% to 2%Hb S: 0%Hb C: 0%In infants and children, these hemoglobin molecules make up the following percentages of total hemoglobin:Hb F (newborn): 50% to 80%Hb F (6 months): 8%Hb F (over 6 months): 1% to 2%Note: Normal value ranges may vary slightly among different laboratories. Talk to your doctor about the meaning of your specific test results.What abnormal results meanThe presence of significant levels of abnormal hemoglobins may indicate:Hemoglobin C diseaseRare hemoglobinopathySickle cell anemiaThalassemiaWhat the risks areThere is very little risk involved with having your blood taken. Veins and arteries vary in size from one patient to another and from one side of the body to the other. Taking blood from some people may be more difficult than from others.Other risks associated with having blood drawn are slight but may include:Excessive bleedingFainting or feeling light-headedHematoma (blood accumulating under the skin)Infection (a slight risk any time the skin is broken)Special considerationsYou may have false normal or abnormal results if you've had a blood transfusion within the previous 12 weeks.ReferencesNagel R. Methemoglobinemias and unstable hemoglobins. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 168.Steinberg M. Sickle cell disease and associated hemoglobinopathies. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 167.
