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In the absence of any regulatory mechanisms what effect do you think an increase in blood pressure would have on glomerular filtration rate?
Generally speaking, it would increase.
However, it depends on the reason for the hypertension. For instance, if there is an obstruction or constriction of the renal artery (stenosis, malignancy, etc...) the physiologic affect would to increase the body's BP. This is due to the fact that the obstruction is decreasing hydrostatic pressure to the glomerulus, and transiently decreasing GFR. The body compensates by increasing BP to increase GFR. Patients that present with a renal artery stenosis could in fact be hypertensive with a decreased GFR.
What else can I help you with?
How does glomerular hydrostatic pressure effect filtration rate?
Glomerular hydrostatic pressure is the primary driving force for filtration rate in the kidneys. An increase in glomerular hydrostatic pressure will increase the rate of filtration by pushing more fluid and solutes out of the blood and into the renal tubules. Conversely, a decrease in glomerular hydrostatic pressure will decrease the filtration rate.
What is the effect of constricted arterioles in the glomerular filtration rate?
Constricted arterioles in the glomerulus can lead to a decrease in the glomerular filtration rate (GFR) by reducing the amount of blood flow entering the glomerulus. This can result in decreased filtration of waste and reduced urine production.
How do you increase your GFR?
To increase your glomerular filtration rate, blood flow needs to be increased to the kidneys and the impaired kidneys function restored. The glomerular filtration rate, of GFR, measures how much blood passes through the glomeruli into the kidneys each minute.
Macula densa feedback (tubuloglomerular feedback) decrease or increase?
The macula densa is involved in tubuloglomerular feedback to help regulate glomerular filtration rate. An increase in NaCl concentration at the macula densa leads to vasoconstriction of the afferent arteriole, decreasing glomerular filtration rate. Conversely, a decrease in NaCl concentration leads to vasodilation of the afferent arteriole, increasing glomerular filtration rate.
What condition would lead to an increase in the amount of fluid entering the bowmans capsule?
An increase in blood pressure or an increase in blood volume can lead to an increase in the amount of fluid entering Bowman's capsule (glomerular filtration rate) due to increased glomerular blood flow. This can be seen in conditions such as hypertension or congestive heart failure.
What regulatory mechanisms would occur in response to a sudden increase in blood pressure?
Sudden vasodilation
Why would a decrease in plasma protein concentration cause an increase in GFR?
A decrease in plasma protein concentration can reduce the oncotic pressure in the blood vessels, leading to less water reabsorption in the kidneys and more water remaining in the filtrate. This increased water in the filtrate can increase the pressure in the glomerular capillaries, resulting in an increase in glomerular filtration rate (GFR).
Dilation of the afferent arteriole decrease GFR?
Dilation of the afferent arteriole increases blood flow into the glomerulus, leading to an increase in glomerular filtration rate (GFR) due to the increased pressure on the filtration membrane. This can result in increased urine production.
How could adjust the afferent or efferent radius to compensate for the effect of reduced blood pressure on glomerular filtration rate?
increase afferent radius or decrease efferent radius depending on the degree of change in blood pressure
What is the effect of decrease of Plasma protein concentration on Glomerular Filtration rate GFR?
A decrease in plasma protein concentration can lead to a reduction in oncotic pressure within the blood vessels, which affects the balance of forces governing glomerular filtration. This reduction in oncotic pressure may result in increased filtration of fluid into the Bowman’s capsule, potentially causing edema and altering the normal filtration dynamics. Consequently, while the initial response may be an increase in GFR due to decreased resistance against filtration, prolonged low plasma protein levels can ultimately impair kidney function and lead to a decrease in GFR over time.
What is regulatory mechanisms?
Regulatory mechanisms are those that are systems of contol in keeping the internal environment relatively stable and maintained within narrow limits, despite external environment change. Mechanisms like this include the Negative Feedback system, in which change in a variable is detected (e.g. increase) and action occurs to produce a change in the opposite direction (e.g. decrease).
Why does blood get filtered by the kidneys?
Blood pressure promotes filtration of blood in the kidneys by, generally, being greater in pressure than blood colloid osmotic pressure and glomerular capsule pressure which produces a net filtration pressure of about 10 mm Hg. Net filtration pressure forces a large volume of fluid into the capsular space. When blood pressure increase or decreases slightly, changes in the diameters of the afferent and efferent arterioles can actually keep net filtration pressure steady to maintain normal glomerular filtration. Constriction of the afferent arteriole decreases blood flow into the glomerulus, which decreases net filtration pressure. Constriction of the efferent arteriole slows outflow of blood and increases net filtration pressure.
