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Yes and no. It is degenerative in the sense that it damages neurons in cognitive and emotional areas of the brain (in a similar fashion that Parkinson's Disease damages neurons in parts of the brain that control motor function), especially if depression goes undiagnosed and untreated over a long period of time. But it is NOT thought to be degenerative in the sense that it's a progressive illness. In other words, the damage caused by depression can be reversed, and your brain can heal itself overtime, repairing those damaged neurons and re-connecting broken synapses IF you are taking a proper course of treatment, which usually involves an anti-depressant combined with enrichment exercises, lifestyle changes, and/or psychological therapy.

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