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Diabetes mellitus is not caused by a hypersecretion of insulin. A person with diabetes either produces too little insulin, or a normal amount of insulin that is not recognized by other cells in the body.

Diabetes is caused by a lack of effective insulin. In type 1 diabetes the pancreatic beta cells are not producing sufficient insulin. Type 2 diabetes occurs when insulin sensitivity in target cells has decreased, so the insulin is no longer causing glucose uptake.

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