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As the question suggests, both low and high blood pressures can lead to kidney injury (previously called "kidney failure"). Low blood pressure decreases the blood flow to the kidney, and since the kidney's function depends on adequate blood flow, it may not be able to do its job at such a low blood pressure. Consequently, the glomerular filtration rate (GFR), a measure of kidney function, may drop; a low GFR is one measure of kidney injury. If the low blood pressure persists, not only does kidney function decrease, but the kidneys can actually become damaged. Low blood flow can lead to inadequate oxygen delivery to the kidney, which can cause the cells of the kidney to fall apart, die, and leak fluid. All of these are types of so-called acute kidney injury.

High blood pressure can cause proteins to leak into the kidney inappropriately so that protein ends up in the urine (called proteinuria). Long-term proteinuria damages the filtering component of the kidney, which can rapidly lead to acute kidney injury. In addition, high blood pressure can lead to a condition called arteriolar nephrosclerosis, wherein the leaked pressures get into the walls of the kidney's blood vessels, decreasing their ability to do their job. moreover very high blood pressure would disturb the blood composition by eliminating useful components to the urinary system...therefore damaging the important function of kidney , subsequently leading to "kidney failure"

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