Is sickle cell disease more common in boys or girls?

Answer 1

The incidence of sickle cell disease is equal in both men and women.

However, it is believed that men who have the disease experience worse symptoms than women with the disease.

A possible reason for this is the role of oestrogen in the female body. Oestrogen helps stimulate the production of nitric oxide. Scientists believe that nitric oxide has a key role to play in reducing the symptoms of a sickle cell crisis as it dilates blood vessels, giving the sickle shaped cells more room to pass through the vessels, preventing blockages which is the cause of sickle cell crisis.

Answer 2

Males. Females 95% of the time are just carriers. That 5 other percent are called manifesting carries. They have DMD too, but it usually is not as severe.