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Not directly. Mastoiditis is an infection normally affecting the bone. Epilepsy is a physical condition from the brain. It is possible for someone to have both, but that is not to say they have epilepsy because of their mastoiditis. Anything that can damage the brain could in turn cause seizures as a result of that damage. Mastoiditis can cause an infection in the brain, but nowadays it is a condition that is well controlled and easy to cure, so it rarely causes any major problems.

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