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When discussing blood types, the two groupings most commonly used are the ABO (A, B, AB, O) and Rh (+, -) systems. The least common blood type in humans is Bombay (EXTREMELY rare), which is a type O with missing H antigen. Otherwise, of the "normal" ABO and Rh typings, the least common group is AB-. ABO from most to least frequent: O, A, B, AB. The relative frequencies of these groups varies depending on race. The relative frequences of Rh+ and Rh- individuals also varies with race. About 85% of "whites" are Rh+, while 99.8% of American Indians are Rh+.

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