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Olfactory receptors send axons through the cribriform plate of the ethmoid bone and synapse on neurons in the olfactory bulb. These neurons process olfactory information and transmit signals to higher brain regions, including the olfactory cortex, for further interpretation of smells. The olfactory bulb plays a critical role in the initial stages of olfactory perception.

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What is the function of a cribiform plate?

Small unmyelinated axons from olfactory receptor bipolar neurons (originating in the olfactory epithelium of the nasal cavity) pass through small holes in the cribriform plate of the ethmoid bone. These small nerves are primary sensory neurons that synapse with the olfactory bulb of Cranial Nerve 1 (olfactory nerve) which lies on top of the cribriform plate. These olfactory receptor neurons bind to different types of odorant molecules and, depending on the type of receptor and odorant molecule, fire action potentials which are transmitted to the brain and perceived as recognizable odors. Specifically these are called the Fila Olfactoria.


What bones house the canal in which olfactory neurons pass to reach the nasal cavity?

The olfactory neurons pass through the cribriform plate of the ethmoid bone to reach the nasal cavity. This plate contains numerous small foramina that allow the olfactory nerve fibers to extend from the olfactory bulbs to the nasal epithelium. The ethmoid bone is located between the eyes and forms part of the nasal cavity and the base of the skull.


What passes through cribiform plate?

Small unmyelinated axons from olfactory receptor bipolar neurons (originating in the olfactory epithelium of the nasal cavity) pass through small holes in the cribriform plate of the ethmoid bone. These small nerves are primary sensory neurons that synapse with the olfactory bulb of Cranial Nerve 1 (olfactory nerve) which lies on top of the cribriform plate. These olfactory receptor neurons bind to different types of odorant molecules and, depending on the type of receptor and odorant molecule, fire action potentials which are transmitted to the brain and perceived as recognizable odors. Specifically these are called the Fila Olfactoria.


How do olfactory receptors send axons through the cribriform plate?

Olfactory receptor neurons extend axons through tiny channels in the cribriform plate called olfactory foramina. These axons then travel through the olfactory nerve to the olfactory bulb in the brain, where they synapse with other neurons to transmit smell signals. The olfactory foramina allow for the passage of these axons while protecting the brain from potential pathogens or irritants in the nasal cavity.


Do olfactory receptors synapse with mitral cells in the olfactory bulb?

Yes, olfactory receptors synapse with mitral cells in the olfactory bulb. When odor molecules bind to olfactory receptors in the nasal epithelium, they activate sensory neurons that send signals to the olfactory bulb. In the olfactory bulb, these sensory neurons synapse with mitral cells, which then relay the olfactory information to higher brain regions for processing. This synaptic connection is crucial for the perception of smell.


Where are olfactory receptors located?

Olfactory receptors are located in the nasal cavity, specifically in the olfactory epithelium. This specialized tissue lines the upper part of the nasal cavity and contains millions of olfactory receptor cells that are responsible for detecting smells.


What structures are the receptors for the sense of smell?

The receptors that actually bind with the molecules that we smell are called Olfactory receptor neurons. They pass their signal through the caribform plate, then down the olfactory nerve, and finally to the olfactory bulb in the brain.


What is in charge of your olfactory system?

The mechanism of the olfactory system can be divided into a peripheral one, sensing an external stimulus and encoding it as an electric signal in neurons, and a central one, where all signals are integrated and processed in the central nervous system. The peripheral olfactory system receptors are connected to bipolar olfactory receptor neurons in the olfactory epithelium. Fot the central olfactory system, axons from the olfactory sensory neurons converge in the olfactory bulb.


Why do you think mucus production is important in the olfactory epithilium?

Mucus production in the olfactory epithelium helps to dissolve odorants and deliver them to the olfactory receptors for detection. It also helps to protect the delicate olfactory neurons from damage and maintains the appropriate microenvironment for the receptors to function effectively.


What are the only neurons in the body to routinely undergo mitosis?

The olfactory receptor neurons in the nose are the only neurons in the body that routinely undergo mitosis to replace damaged or aging cells. Other neurons in the central nervous system typically do not undergo mitosis and have limited capacity for regeneration.


How do basal cells contribute to olfaction?

Basal cells are stem cells in the olfactory epithelium that can regenerate olfactory sensory neurons. They differentiate into new olfactory sensory neurons to replace damaged or dying cells, helping maintain the olfactory sensory system's ability to detect and transmit odor information to the brain.


What is the stimulus response pathway involving nose?

When an odorant molecule enters the nose, it binds to specialized receptors in the olfactory epithelium. This triggers a signal cascade that ultimately leads to the activation of sensory neurons. These neurons transmit the signal to the olfactory bulb in the brain, where the odor is processed and interpreted.