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What results from the hereditary lack of intrinsic factor?
Pernicious anemia (vitamin B 12 deficiency)
The lack of this substance produced by the stomach lining can cause pernicious anemia?
The substance that, when lacking, can cause pernicious anemia is intrinsic factor. Intrinsic factor is a glycoprotein produced by the stomach lining, essential for the absorption of vitamin B12 in the intestines. Without sufficient intrinsic factor, the body cannot properly absorb vitamin B12, leading to a deficiency that results in pernicious anemia, characterized by fatigue, weakness, and neurological issues. Treatment typically involves vitamin B12 injections or high-dose oral supplements.
Inadequate intrinsic factor is associated with?
Inadequate intrinsic factor is associated with vitamin B12 deficiency, as intrinsic factor is necessary for the absorption of this essential nutrient in the gut. Vitamin B12 deficiency can lead to symptoms such as anemia, fatigue, and neurological problems. It is commonly seen in individuals with pernicious anemia or autoimmune conditions affecting the stomach lining.
What cause pernicious anemia?
Pernicious Anemia is caused by a lack of intrinsic factor (usually). There can be other causes, such as infection, surgery, medicines taken, or diet.
What anemia can be diagnosis by gastric analysis?
Pernicious Anemia
How pernicious anemia cause achlorhydria?
pernicious anemia is a vitamin B12 deficiency. Vitamin B12 requires Intrinsic Factor to be reabsorbed by the ileum. Intrinsic Factor is produced by parietal cells in stomach. If there is some damage or manipulation of parietal cells, which also produce HCl, there will be less of both intrinsic factor causing B12 deficiency and HCl causing achlorhydria.
What is the function of the intrinsic factor?
Intrinsic factor is necessary for the proper absorption of vitamin b12 which is necessary for red blood cell maturation, and therefore prevents pernicious anemia
Why oral administration of vitamin B12 not effective as a treatment of pernicious anemia?
Pernicious anemia is due to a deficiency of a vitamin called intrinsic factor, which is normally produced by cells of the stomach. Intrinsic factor is required for the absorption of vitamin B12, so if intrinsic factor levels are insufficient, vitamin B12 will not be absorbed well. So administration of vitamin B12 will only help treat vitamin B12-deficiency anemia if vitamin B12 can be absorbed, and this can only happen if there are adequate levels of intrinsic factor to begin with. Patients with pernicious anemia do not have adequate intrinsic factor levels, so they will not be helped by vitamin B12 treatment since they can't absorb it well enough.
Does Pernicious anemia run in families?
Pernicious anemia seems to run in families
What is the prognosis for pernicious anemia?
Prognosis is generally good for patients with pernicious anemia
What is the result of the loss of intrensic factor called?
The loss of intrinsic factor leads to a condition known as pernicious anemia. Intrinsic factor is a protein essential for the absorption of vitamin B12 in the intestines, and its deficiency results in impaired B12 absorption. This can lead to symptoms such as fatigue, weakness, and neurological issues due to the resulting anemia and potential nerve damage.
Why do you need intrinsic factor?
Intrinsic factor or gastric intrinsic factor is a protein produced by the stomach. It is used to absorb vitamin B12 in the small intestine. When there is a deficiency of the Intrinsic factor, there is a deficiency in the absorption of B12 into the body and this leads to pernicious anemia.
