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Maybe, depending on which type of flu vaccine you will be taking. Acyclovir is an antiviral medication that can be used for influenza treatment, but is also used for other types of viral infections. According to the Centers for Disease Control and Prevention:

"It is not known whether administering influenza antiviral medications affects the safety or efficacy of live attenuated influenza vaccine (LAIV); LAIV should not be administered until 48 hours following cessation of influenza antiviral therapy, and influenza antiviral medications should not be administered for 2 weeks following receipt of LAIV."

For additional information about this and about contraindications in other situations, please see the CDC Guide to Contraindications for Vaccines at the link provided in the related links section of this page.

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