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If you happen to be looking at a nuclear bomb without protection at the moment of explosion you will receive permanent retinal burns from the UV radiation. The US Military actually did effects experiments in the 1950s using sheep with their eyelids clamped open so they could verify this and found "upside down mushroom shaped burns" on the retinas of those sheep.

Even with protection from the UV you may experience temporary flash blindness due to the brightness of the visible light bleaching the pigments in the rod and cone cells in the retina.

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