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Irritant receptors:-Irritant receptors lie between airway epithelial cells. They are stimulated by mechanical stimuli, inhaled dusts, cold air, noxious gases and cigarette smoke. The receptors show rapid adaptation when they are continuously stimulated. Impulses travel via myelinated fibers in the vagus nerve.

Irritant receptors lie betw

Irritant receptors in more peripheral bronchi are insensitive to mechanical irritants, but they are sensitive to chemical stimuli; the pattern is reversed in the central airways. Reflex effects include bronchoconstriction and hyperpnoea.

Irritant receptors are also sensitive to histamine and can thus contribute to the bronchoconstrictor response in asthmatic subjects in whom histamine is released from mast cells or other cells.

een airway epithelial cells. They are stimulated by mechanical stimuli, inhaled dusts, cold air, noxious gases and cigarette smoke. The receptors show rapid adaptation when they are continuously stimulated. Impulses travel via myelinated fibers in the vagus nerve.

Irritant receptors are also sensitive to histamine and can thus contribute to the bronchoconstrictor response in asthmatic subjects in whom histamine is released from mast cells or other cells.

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