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Inclusion Body Myositis (IBM) and Polymyositis (PM) are both inflammatory muscle diseases, but they have distinct characteristics. IBM primarily affects older adults, causing progressive muscle weakness and atrophy, particularly in the quadriceps and finger flexors, often with the presence of specific protein aggregates in muscle fibers. In contrast, PM typically affects younger individuals and is characterized by symmetrical muscle weakness without the inclusion bodies found in IBM. Additionally, treatment responses differ, with PM generally responding better to immunosuppressive therapies than IBM.
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Which disorders are classified as subtypes of inflammatory myopathy?
The IMs include dermatomyositis, polymyositis, and inclusion body myositis.
What are the inflammatory myopathies?
The causes of IM are not known. An autoimmune process is likely, as these conditions are often associated with other autoimmune diseases and because they respond to immunosuppressive medication.
What medical term means a disease characterized by the simultaneous inflammation of voluntary muscles in many parts of the body?
Myositis is a general term for inflammation of the muscles. There can be several causes. The most common being polymyositis and dermatomyositis.
What are other types of myopathy or inflammatory muscle disease?
Dermatomyositis (DM) and inclusion body myositis and juvenile dermatomyositis.
When was IBM inclusive body myositis first diagnost?
Inclusion Body Myositis, IBM, which is a rare inflamitory muscular disease, was first diagnosed in 1971, by Yunis and Samaha. IBM is a degenerative disorder that typically affects people over 50 but it is not comsidered terminal.
When did Ronald Sukenick die?
Ronald Sukenick died on July 22, 2004, in New York City, New York, USA of inclusion body myositis.
What is inclusive body myositis?
Inclusion body myositis (IBM) is an inflammatory muscle disease characterized by progressive muscle weakness and wasting. The common feature of IBM is the abnormal finding of inclusion bodies, or granular material, in muscle fibers.
What are the effects of polymyositis?
It causes muscles to exhibit varying degrees of decreased strength, usually affecting those muscles that are closest to the trunk of the body. Trouble with swallowing (dysphagia) may occur with polymyositis.
Is IBM an autoimmune disease?
No, IBM, or Inclusion Body Myositis, is not classified as an autoimmune disease. It is a progressive inflammatory muscle disorder characterized by muscle weakness and wasting, primarily affecting the proximal muscles. While autoimmune mechanisms may play a role in its pathology, it is distinct from typical autoimmune diseases, which involve an immune response against the body's own tissues.
What else is cytomeglic inclusion body disease known as?
Cytomegalic inclusion body disease is also known as giant cell inclusion disease, cytomegalovirus infection, and salivary gland disease.
What are the causes of myositis?
Myositis is thought to be an autoimmune disease. The body normally fights infections and disease by producing antibodies and white blood cells called lymphocytes in a process called the immune response. In an autoimmune disease.
What does Polymyositis produce?
Polymyositis is an inflammatory muscle disease that causes muscle weakness, typically in the muscles closest to the trunk of the body. It can lead to difficulties with climbing stairs, rising from a chair, or lifting objects. Other symptoms may include fatigue, weight loss, and muscle pain.
