Crospovidone is generally considered safe for use in pharmaceuticals and food products as an excipient; however, potential dangers include allergic reactions in sensitive individuals, which may lead to symptoms like itching, swelling, or respiratory issues. In rare cases, inhalation of crospovidone dust can cause respiratory irritation. Additionally, improper use or excessive amounts in formulations could lead to gastrointestinal disturbances. Always consult safety data sheets and guidelines for proper handling and usage.
Crospovidone and croscarmellose are both types of super-disintegrants used in pharmaceutical formulations to help tablets break down quickly in the digestive system. Crospovidone is a synthetic polymer made from N-vinylpyrrolidone, while croscarmellose is a cross-linked sodium carboxymethylcellulose. Crospovidone tends to have faster disintegration properties compared to croscarmellose.
Molecular.See the Related Questions to the left for how to determine if a molecule is molecular of ionic.
Insoluble polyvinylpyrrolidone has its name Crospovidone in the pharmaceutical industry and PVPP (abbreviation of polyvinylpolypyrrolidone) in the beverages industry. It is crosslinked polyvinylpyrrolidone, white or yellowish to white free flowing powder practically without odor, which is insoluble in water, alkali, acid and usual solvents. It has good swelling characteristics in water without forming a gel. Crospovidone has been used in the manufacture of different pharmaceutical products. Because of its swelling property,i t is used as a disintegrant in tablets, granules and Gelatin capsules. Also, the ability of crospovidone to stabilize suspensions finds its most important application in antibiotics, antacids and vitamin preparations. In the beverages industry, crospovidone (known as PVPP) is used to stabilize/clarify beer and wine by absorbing the polyphenols that cause chill-haze in beer. Clearer and more stable products can be obtained by introducing PVPP into the brewing process.
Ciprofloxacin hydrochloride, cornstarch, microcrystalline cellulose, silicon dioxide, crospovidone, magnesium strearate, hypromellose, titanium dioxide and polyethylene glycol.
Crospovidone (without -r-) is another name for polyvinylpyrrolidone (PVP, (C6H9NO)n ).This is a water-soluble polymer made from the monomer N-vinylpyrrolidone (C6H9NO).
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