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Congenital antithrombin III deficiency?
DefinitionCongenital antithrombin III deficiency is a genetic disorder that causes the blood to clot more than normal.Alternative NamesDeficiency - antithrombin III - congenital; Antithrombin III deficiency - congenitalCauses, incidence, and risk factorsAntithrombin IIIis a protein in the blood that naturally blocks blood clots from forming. Congenital antithrombin III deficiency is an inherited disease. It occurs when a person receives one abnormal copy of a gene from a parent with the disease.The abnormal gene leads to low levels of antithrombin III. These low levels of antithrombin III can cause abnormal blood clots (thrombi) that may damage organs.Often, patients with this condition will have a blood clot at a young age and will have a family member who has also experienced a blood clotting episode.SymptomsPatients will usually have symptoms of a blood clot, including:Coughing up bloodFaintingShortness of breath and pain when taking deep breathsSwelling of one legSigns and testsA physical examination may show:A fast heart rateA swollen foot or ankleThe diagnosis is made by checking for low levels of antithrombin III in the patient's blood.TreatmentA blood clot is treated with blood thinning medications or anticoagulants. How long you need to take these medications depends on how serious the blood clot was and other factors. Discuss this with your health care provider.Expectations (prognosis)Most patients have a good outcome if they stay on anticoagulant medications.ComplicationsBlood clots can cause death, especially if they are in the lungs.Calling your health care providerSee your health care provider if you have symptoms of this condition.PreventionBecause this is an inherited condition, there is no way to prevent it. However, once a patient is diagnosed with antithrombin III deficiency, all close family members should be screened.ReferencesSchafer A. Thrombotic disorders: Hypercoagulable states. In: Goldman L, Ausiello D. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier;2007:chap 182.
What is the name of the natural anticoagulant found in the blood?
Heparin, the natural anticoagulant contained in basophil and mast cell granules. It inhibits thrombin by enhancing the activity of antithrombin III. Heparin also inhibits the intrinsic pathway. antithrombin III and protein c inhibit the activity of other intrinsic pathway procoagulants.
What is betaine deficiency?
What are some symptoms of deficiency of betaine
Why blood does not clot in circulation?
I. Endothelial surface factors- a) Smoothness of endothelial surface,which prevents contact activation of intrinsic system. b) Layer of glycocalyx on endothelium. c) a protein bound with the endothelium membrane, thrombomodulin, which binds thrombin. II. Antithrombin action of fibrin & Antithrombin-III a) when a clot is forming, about 85-90% of thrombin becomes adsorbed to fibrin fibers. b) some thrombin 10-15%, combines with antithrombin-III, which urther blocks effect of thrombin on fibrinogen. III. Heparin- heparin is a highly negatively charged conjugated polysaccharide.
What is an antithrombin?
An antithrombin is a small molecule which inactivates several enzymes of the coagulation system.
What are some symptoms of vitamin deficiency?
There are many symptoms associated with vitamin deficiency. Some examples of these symptoms include fatigue, dizziness, and mental confusion or forgetfulness.
What are some Vitamin D deficiency symptoms?
There are many Vitamin D deficiency symptoms and here are the most common ones:ricketsosteoporosisobesityfatiguechronic backachecancersDiabetesHeart diseaseshyperparathyroidismdepression
Is long time lapse between the nutritional deficiency and the clinical symptoms of a limitation of Nutritional Assessment?
Nutritional deficiency and its symptoms A list of essential Nutrients, incidence of its deficiency and the typical symptoms and diseases are given.Nutrition disorder wicked , the free encyclopedia. These include, but are not limited to , deficiency diseases, caused by a lack of essential nutrition naves disorders , symptoms sign/eponymous.
What are the symptoms for vitamin D deficiency?
Some of the symptoms of vitamin D deficiency include bone pain and muscle weakness. These symptoms are usually subtle though, so if one is at risk of this deficiency, blood tests would be recommended to check the levels of this vitamin.
List of deficiency diseases and their symptoms?
Rickets in children and osteomalacia are examples of deficiency diseases due to vitamin deficiency. Scurvy is an example of vitamin C deficiency. Beriberi is an example of vitamin B one deficiency. (Both, wet beriberi and dry beriberi.) Pellagra is an example of Niacin deficiency. Anemia is caused by deficiency of vitamin B 12 and Folic acid. Burning feet syndrome is caused by the deficiency of Pantothenic acid. Night blindness is caused by the deficiency of vitamin A. Kwashiorkor and marasmus are caused by deficiency of proteins and food, respectively. Poverty is caused by deficiency of kindness. Inequality is caused by deficiency of compassion.
What range of symptoms may result from enzyme deficiency?
The severity of the symptoms depends on the extent of the enzyme deficiency, and range from a feeling of mild bloating to severe diarrhea.
What are the common symptoms of vitamin deficiency that can lead to chapped lips?
Common symptoms of vitamin deficiency that can lead to chapped lips include dryness, cracking, and inflammation of the lips.
