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Thromboplastin -> Prothrombin -> Thrombin -> Fibrinogen -> Fibrin

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Prothrombin converts prothrombin to?

Prothrombin is converted to thrombin by the enzyme thromboplastin. Thrombin plays a vital role in the clotting cascade by converting fibrinogen into fibrin, which forms a mesh that helps stop bleeding.


How blood is preserved without getting coagulated in blood bank?

When there is an injury and blood flows, a mechanism is provided within the body whereby blood loss is prevented. This is termed as the coagulation or clotting of blood. The actual mechanism of blood coagulation is a complicated one, but the general principles are simple and important. Before clotting, there are some substances which must be present in the blood. They are prothrombin, calcium, fibrinogen and thromboplastin. Prothrombin, calcium and fibrinogen are all normal constituents of blood. But thromboplastin is released only when there is a damage in a blood vessel or tissue cell the release of thromboplastin from thrombocytes or blood platelets brings about a series of changes or events which finally produces a blood clot. Normally, prothrombin (protein present in the plasma) as such is inactive, but when acted upon thromboplastin in the presence of calcium is converted to an active substance thrombin. Thrombin in turn acts on fibrinogen, another plasma protein, to produce an in soluble thread-like substance called fibrin. The fibrin threads entrap blood cells to form a solid mass, the clot. After sometimes the clot shrinks', and a clear stickle fluid, serum is released, (Serum=plasma-fibrinogen). The mechanism of clotting can be expressed in a simple formula: 1. Prothrombin + Calcium+thromboplastin = Thrombin (active) (inactive) (from damaged tissue cells and platelets) 2. Thrombin + fibrinogen = Fibrin (fine threads) (inactive) 3. Fibrin + blood cells = CLOT Certain factors or conditions hasten the clotting of blood, while others retards


How does Heparin prevents blood from clotting?

inhibiting the formation of prothrombin activator and the action of thrombin on fibrinogen


What is the Sequence blood clotting?

Prothrombin-->Thrombin; Fibrinogen--> Fibrin (activated by thrombin)The sequence of blood clotting is called Coagulation.


What cellular component in the blood is crucial in blood clotting?

platelets.


Does heparin prevent blood from clotting?

inhibiting the formation of prothrombin activator and the action of thrombin on fibrinogen


What are the name of clotting factors?

thorton jean will bill mark Andy and ellathrombin,prothrombin,fibrin and fibrinogen and platelets are clotting factors.


Does whole blood have clotting factors?

Yes, whole blood contains clotting factors such as fibrinogen, prothrombin, and platelets that help initiate the blood clotting process.


What is the function of thromboplastin in homeostasis?

In the final step of blood clotting cascade, Thromboplastin activates the prothrombin to Thrombin. Then the activated thrombin helps in the conversion of Fibrionogen into Fibrin (Mesh like fibrils which forms the clot).


What coagulation factors are measured by the PT?

Prothrombin time (PT) measures the activity of coagulation factors in the tissue factor pathway of the coagulation cascade.


Would prothrombin amd fibrinogen be best described as clotting factors?

Yes, they are both found in the cascade effect the body uses when stopping blood flow after injury.


What is blood clotting?

There are the intrinsic and extrinsic pathways in clotting. The intrinsic pathway is initiated when blood comes in contact with damaged endothelium or collagen, and involves clotting factors XII, XI, IX, and VIII. The extrinsic pathway is activated when being exposed to tissue factor from tissue injury or the addition of thromboplastin to blood, and involves clotting factor VII. The two pathways meet at the point of clotting factor X activation to lead the final common pathway. From here, factor X is converted to prothrombin, prothrombin to thrombin, thrombin to fibrinogen, fibrinogen to fibrin, and finally fibrin to fibrin clot. Platelets, activated by thrombin, adhere to the damaged endothelium wall or collagen to form a plug. At the same time, they activate clotting factors VII and X. More platelets are stimulated by fibrin clots, resulting in reinforcing the formed clots.