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There are a few differences actually. Firstly, the skin on your palms (includes palm-side of entire hand) and the bottom of your feet is thick skin, whereas the rest of your body is covered in thin skin (with your eyelids being the thinnest). Thick skin has a fifth layer in the epidermal stratum, the stratum lucidum, that lies above the stratum granulosome and is not found in thin skin.

Also, since the fingertips are highly receptive to light touch, they are one of the few places that have Meissner's corpuscles. Meissner's corpuscles are the most sensitive (to touch) nerve endings in the skin. They can also be found in the lips, palms, soles of your feet and tongue.

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