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Blood groups are classified based on the presence or absence of specific antigens on the surface of red blood cells. The main blood group systems are A, B, AB, and O, which are determined by the ABO blood group system. Group A has A antigens, group B has B antigens, group AB has both A and B antigens, and group O has neither. Additionally, the Rh factor can be positive or negative, further categorizing blood types into eight distinct groups: A+, A-, B+, B-, AB+, AB-, O+, and O-.

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