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Atherosclerosis, which is a buildup of fatty deposits in the arteries of the body affects all of the arteries in the body. The end result of long-term buildup of these deposits are usually seen first in the nervous system (stroke), heart (heart attack) and legs (claudication).

Specifically, in the heart, buildup of fatty plaques causes narrowing of the lumen of the coronary arteries. Over time, this narrowing may get so severe that it reduces the amount of blood that can get through to the heart muscle supplied by that artery. This causes anginal symptoms, typically, but not heart attacks. Heart attacks are caused by a rupture of the fatty plaque, which results in clot formation in the vessel, stopping all blood flow to the heart muscle.

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16y ago

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