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In cardiovascular health, heart valves are located between atria and ventricles in the heart. The valves will open significantly during the atrial depolarization, or contraction of the atria. During the subsequent re-polarization of the atria and depolarization of ventricles, the valves are pushed in the opposite direction and shut closed. This mechanism allows the flow of blood in one single direction only, from atria to ventricle.

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