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Systemic circulation is the portion of the cardiovascular system which carries oxygenated blood away from the heart, to the body, and returns deoxygenated blood back to the heart.

Arteries always take blood away from the heart, regardless of their oxygenation, and veins always bring blood back. In general, arteries bring oxygenated blood to the tissues; veins bring deoxygenated blood back to the heart. In the case of the pulmonary vessels, however, the oxygenation is reversed: the pulmonary artery takes deoxygenated blood from the heart to the lungs, and oxygenated blood is pumped back through the pulmonary vein to the heart. As blood circulates through the body, oxygen and nutrients diffuse from the blood into cells surrounding the capillaries, and carbon dioxide diffuses into the blood from the capillary cells.

The release of oxygen from red blood cells or erythrocytes is regulated in mammals. It increases with an increase of carbon dioxide in tissues, an increase in temperature, or a decrease in pH. Such characteristics are exhibited by tissues undergoing high metabolism, as they require increased levels of oxygen.

Pulmonary circulation is the portion of the cardiovascular system which carries oxygen-depleted blood away from the heart, to the lungs, and returns oxygenated blood back to the heart.

De-oxygenated blood enters the right atrium of the heart and flows into the right ventricle where it is pumped through the pulmonary arteries to the lungs. Pulmonary veins return the now oxygen-rich blood to the heart, where it enters the left atrium before flowing into the left ventricle. From the left ventricle the oxygen-rich blood is pumped out via the aorta, and on to the rest of the body.

The Coronary circulatory system provides a blood supply to the heart.

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