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Some of the rarest neurological disorders include Stiff Person Syndrome, Moyamoya Disease, Friedreich's Ataxia, Kufs Disease, Neuromyelitis Optica, Syringomyelia, Bickerstaff's Brainstem Encephalitis, Rasmussen's Encephalitis, Chorea-acanthocytosis, and Wolfram Syndrome. These conditions often present unique challenges, including severe symptoms and limited treatment options, making them particularly difficult to diagnose and manage. Their rarity often leads to under-researched and underfunded awareness efforts.

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