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How many drugs have been approved for use against HIV?
There is no cure for HIV, however the drug classes that are used to treat HIV are Non-nucleoside reverse transcriptase inhibitors (NNRTIs), Nucleoside reverse transcriptase inhibitors (NRTIs), Protease inhibitors (PIs), Entry or fusion inhibitors, and Integrase inhibitors
What are non-nucleoside reverse transcriptase inhibitors?
delavirdine (Rescriptor), loviride, and nevirapine (Viramune) act by binding directly to the reverse transcriptase molecule, inhibiting its activity.
What is a calanolide?
A calanolide is any of a family of reverse transcriptase inhibitors extracted from trees of the genus Calophyllum.
What enzyme turns HIV rna into HIV DNA?
The enzyme is called reverse transcriptase. The class of HIV drugs that block this process are called reverse transcriptase inhibitors.
What services does ViiV Healthcare provide?
Viiv Healthcare provides several products and services for HIV treatment. They provide nucleoside reverse transcriptase inhibitors such as Combivir and Epivir and protease inhibitors such as Lexiva and Viracept.
Which is the enzyme that HIV uses to synthesize DNA on an RNA template?
The enzyme that HIV uses to synthesize DNA on an RNA template is called reverse transcriptase. It catalyzes the conversion of viral RNA into DNA, which is an essential step in the HIV replication cycle.
Difference between nucleoside reverse trancriptase inhibitor and non nucleoside reverse transcriptase inhibitor?
They have a different mode of action in inhibiting the transcription of the viral DNA. The NRTI is actually a nucleoside that incorporates into the viral DNA but it does not have a 3-hydroxyl group so it inhibits and halts the continued growth of the viral DNA chain. The NNRTI's bind to the reverse transcriptase and inhibit its movement.
What precautions should be taken when taking non-nucleoside reverse transcriptase inhibitors?
Patients should not discontinue this drug even if symptoms improve without consultation with a physician.
Is AZT is a protease inhibitor?
No, AZT (zidovudine) is not a protease inhibitor; it is an antiretroviral medication classified as a nucleoside reverse transcriptase inhibitor (NRTI). AZT works by inhibiting the reverse transcriptase enzyme, which is crucial for the replication of HIV. Protease inhibitors, on the other hand, target the protease enzyme, preventing the maturation of viral particles.
What adverse effects are possible with nucleoside reverse transcriptase inhibitors?
Lactic acidosis in the absence of hypoxemia and severe liver enlargement with fatty degeneration have been reported with zidovudine and zalcitabine, and are potentially fatal.
How do HIV medications affect the progression of HIV?
HIV treatments must be promptly administered to anyone diagnosed as HIV positive. These treatments slow down the course of the disease. As per WHO, HIV treatments include use of at least three antiretroviral drugs to suppress the HIV virus. Various classes of drugs that are helpful in HIV treatment are non-nucleoside reverse transcriptase inhibitors, protease inhibitors, integrase inhibitors, entry inhibitors, fusion inhibitors, CCR5 receptor antagonists, maturation inhibitors, etc. The drugs bevirimat and vivecon are being investigated for their benefits in HIV treatment.
AZT is used for?
AZT is a medication used to treat AIDS.It belongs to a class of drugs called Nucleoside Reverse Transcriptase Inhibitors (NRTI) that work by inhibiting Reverse Transcriptase, which is an enzyme that converts the virus's RNA into DNA. If the HIV cell is unable to create DNA inside a healthy cell, HIV cannot infect the cell.
