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Encephalitis lethargica primarily affects the basal ganglia, particularly the substantia nigra, and other areas involved in motor control and regulation of wakefulness. It can also impact the midbrain and regions associated with the limbic system, leading to symptoms such as lethargy, movement disorders, and behavioral changes. The exact mechanisms and regions can vary, but the basal ganglia's involvement is a hallmark of the condition.

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1mo ago

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