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The varicella-zoster virus enters through the respiratory system and colonizes the upper respiratory tract. Initial replication is in the nasopharynx and lymph nodes. Four to six days later, the virus spreads through the circulatory system to the cells of the spleen and liver, and to the dorsal nerve ganglia, where it remains for life.

After a week the virus travels to the viscera and skin, causing the typical skin lesions.
the chicken pox effects the nervous system (the nerves to be exact), the integumentary system (the skin), and i think that about covers it.oh and the lymphatic system.

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