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Microcytosis, characterized by smaller-than-normal red blood cells, can be caused by several factors, primarily iron deficiency anemia, where insufficient iron affects hemoglobin production. Other causes include thalassemia, a genetic disorder affecting hemoglobin synthesis, and chronic diseases that impact erythropoiesis. Additionally, lead poisoning and certain nutritional deficiencies, such as vitamin B6 deficiency, can also contribute to microcytosis.

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Microcytosis is commonly associated with iron deficiency anemia. Since the cells are shrinking the red blood cells are taking up less room relative to the plasma and become less packed, thus the ESR decreases.


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Microcytosis is a condition characterized by the presence of smaller-than-normal red blood cells (RBCs) in the bloodstream, often identified through a complete blood count (CBC). It is commonly associated with iron deficiency anemia, thalassemia, and other hemoglobinopathies. Microcytic red blood cells typically have a reduced mean corpuscular volume (MCV) and can indicate underlying nutritional deficiencies or chronic diseases. Diagnosis and treatment depend on identifying the underlying cause of the microcytosis.


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